Risk Factors for Immune Recovery Uveitis in Patients with Cytomegalovirus Retinitis After Hematopoietic Stem Cell Transplantation

PURPOSE: To investigate the risk factors and clinical characteristics of immune recovery uveitis (IRU) in patients with cytomegalovirus (CMV) retinitis after hematopoietic stem cell transplantation (HSCT). METHODS: Clinical variables-including age, sex, type of hematologic disease, survival status, absolute neutrophil count, involved eye, visual acuity, number of intravitreal antiviral injections, recurrence of CMV retinitis, CMV titers in blood and aqueous humor, extent and location of retinal involvement, donor human leukocyte antigen matching, donor relationship, and systemic CMV treatment-were evaluated in patients with CMV retinitis following HSCT. RESULTS: = 0.027, respectively). CONCLUSION: Retinal involvement near the posterior pole, larger affected areas, and a shorter interval between HSCT and CMV retinitis diagnosis are significant risk factors for developing IRU in patients with CMV retinitis after HSCT. Careful monitoring for IRU remains essential even after resolution of CMV retinitis.