Dopaminergic hypersensitivity of the opioid-responsive striatal–entopeduncular pathway in a rodent model of restless legs syndrome
Rs. The results indicate that BID induces an increased dopaminergic sensitivity of the opioid-responsive striatal-EPN pathway, which might represent a pivotal pathogenetic mechanism of the restlessness of RLS and opioid withdrawal.
Authors
- Sergi Ferré (ORCID: https://orcid.org/0000-0002-1747-1779)
- Christopher J. Earley (ORCID: https://orcid.org/0000-0003-4526-7967)
- William N. Sanchez
- Francisco Ciruela (ORCID: https://orcid.org/0000-0003-0832-3739)
- Marta Valle-León
- Sandra Albornoz
- César Quiroz
- Ana M. Rule
- Ning-Sheng Cai
- William Rea
Institutions
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Johns Hopkins University (US)
- Ajuntament de L’Hospitalet (ES)
Publication Details
- Journal
- Neuropsychopharmacology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1038/s41386-026-02413-2
- Primary Topic
- Restless Legs Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health