Novel 3-Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia

Provided herein are novel 3-heteroaryl pyrrolidine and piperidine compounds as orexin receptor agonists, pharmaceutical compositions, use of such compounds in treating sleep disorders, namely, narcolepsy and hypersomnia, and processes for preparing such compounds.

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Publication Details

Journal
ACS Medicinal Chemistry Letters
Published
2026-04-17
DOI
https://doi.org/10.1021/acsmedchemlett.6c00174
Primary Topic
Sleep and Wakefulness Research
Type
article
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article

Novel 3-Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia

Ram W. Sabnis
ACS Medicinal Chemistry Letters
Sleep and Wakefulness Research
article

Novel 3-Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia

Ram W. Sabnis
article en

Abstract

Provided herein are novel 3-heteroaryl pyrrolidine and piperidine compounds as orexin receptor agonists, pharmaceutical compositions, use of such compounds in treating sleep disorders, namely, narcolepsy and hypersomnia, and processes for preparing such compounds.

ACS Medicinal Chemistry Letters
Good health and well-being
Openalex Percentile: Top 12%
Sleep and Wakefulness Research
DOISourceOpenAlex
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Novel 3-Heteroaryl Pyrrolidine and Piperidine Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia — Ram W. Sabnis · ACS Medicinal Chemistry Letters (2026) | TGRS Research Map | TGRS