Drug-resistant clinical <i>Candida</i> responded to 5-aminolevulinic acid photodynamic therapy (ALA-PDT) <i>in vitro</i> via enhanced ROS release
spp. growth by inducing ROS-mediated cell damage and suppressing mycelial gene expression. These findings highlight ALA-PDT as a promising therapeutic approach for refractory candidiasis and provide mechanistic insights into its antifungal activity.
Authors
- Zhiya Yang
- Dongmei Li (ORCID: https://orcid.org/0000-0002-3272-2513)
- Dongmei Shi (ORCID: https://orcid.org/0000-0002-0886-4191)
- Ruoyu Shi
- Yonghong Zhang
- Sisi Wang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Georgetown University (US)
- Sichuan University (CN)
- Georgetown University Medical Center (US)
- West China Hospital of Sichuan University (CN)
- Jining First People's Hospital (CN)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1128/aac.01645-25
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China