Tungsten-Mediated Decarboxylative C(sp <sup>3</sup> )–O Bond Formation through Ligand-to-Metal Charge Transfer
)-O bond formation reaction under mild, base-free conditions with irradiation. This transformation employs readily available carboxylic acids as substrates and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) as oxygenation reagent. The protocol exhibits a broad substrate scope and has been successfully applied to the late-stage functionalization of bioactive molecules.
Authors
- Heng Song (ORCID: https://orcid.org/0000-0002-2340-1208)
- Shu-Fen Hou (ORCID: https://orcid.org/0009-0009-3029-6491)
- Chen Xu (ORCID: https://orcid.org/0000-0003-1589-736X)
- P. Bai
- Siyu He
- Yi Huang
Institutions
- Jiangsu University of Science and Technology (CN)
- Weifang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.joc.6c00328
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Science and Technology Bureau of Zhenjiang