Dual-Lock NIR Dual-Channel Probe: Synchronous Viscosity/HSO <sub>3</sub> <sup>–</sup> Sensing for Visualizing Platinum-Induced Nephrotoxicity and Renoprotector Screening
-acetylcysteine, methylprednisolone, and astragaloside IV). Notably, the combination of DDP with these renoprotective agents effectively alleviated renal injury without compromising the antitumor potency of DDP. Our dual-lock probes thus provide a robust set of chemical tools for deciphering the dynamic fluctuations of multiple pathophysiologically relevant parameters in complex biological systems, assessing drug toxicity, and optimizing combination therapeutic regimens for safe and effective cancer chemotherapy.
Authors
- Siyu Gao (ORCID: https://orcid.org/0000-0003-2634-3557)
- Zhanxian Li (ORCID: https://orcid.org/0000-0003-3816-4206)
- L Yang
- Lulu Zhang
- Wenwen Li
- Jingwen Diao (ORCID: https://orcid.org/0009-0007-3911-8806)
- Shusheng Zhang (ORCID: https://orcid.org/0000-0002-8416-8331)
- Yuechen Zhang
Institutions
- Linyi University (CN)
- Zhengzhou University (CN)
- Shandong Special Equipment Inspection Institute (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.analchem.6c00735
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Henan Provincial Science and Technology Research Project