The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death

. TRIM21 ICs are taken up by macrophages, which drive proinflammatory responses, antigen presentation, and metabolic changes in high interferon environments. Thus, TRIM21 may perpetuate inflammation and autoantigen presentation, resulting in high immunogenicity.

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Publication Details

Journal
Science Immunology
Published
2026-04-17
DOI
https://doi.org/10.1126/sciimmunol.ads9680
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00

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article

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death

Benjamin A. Fisher, Benjamin Demarco, Madelon M.E. de Jong, Alexander J. Clarke et al.
Science Immunology
interferon and immune responses
article

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death

Benjamin A. Fisher, Benjamin Demarco, Madelon M.E. de Jong, Alexander J. Clarke, Lynn B. Dustin, Ryan Glass, Audrey Gérard, Gemma Harris, Sarah Hill, Yavuz F. Yazicioglu, Jelena S. Bezbradica, Mark Steven Cragg, Saba Nayar, Joannah R. Fergusson, G.M. Mead, Marcus Widdess, Esther L. Jones Evans
article en

Abstract

. TRIM21 ICs are taken up by macrophages, which drive proinflammatory responses, antigen presentation, and metabolic changes in high interferon environments. Thus, TRIM21 may perpetuate inflammation and autoantigen presentation, resulting in high immunogenicity.

Science ImmunologyVol. 11(118)
University of Oxford (GB), Research Complex at Harwell (GB), NIHR Birmingham Biomedical Research Centre (GB), University of Southampton (GB), Quest Diagnostics (United States) (US), University of Birmingham (GB)
Wellcome Trust, Kennedy Trust for Rheumatology Research, National Institute for Health and Care Research, Medical Research Council, Birmingham Biomedical Research Centre
Good health and well-being
Openalex Percentile: Top 14%
interferon and immune responses
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