The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death
. TRIM21 ICs are taken up by macrophages, which drive proinflammatory responses, antigen presentation, and metabolic changes in high interferon environments. Thus, TRIM21 may perpetuate inflammation and autoantigen presentation, resulting in high immunogenicity.
Authors
- Benjamin A. Fisher (ORCID: https://orcid.org/0000-0003-4631-549X)
- Benjamin Demarco (ORCID: https://orcid.org/0000-0002-5537-1381)
- Madelon M.E. de Jong (ORCID: https://orcid.org/0000-0002-6145-6154)
- Alexander J. Clarke (ORCID: https://orcid.org/0000-0003-2846-7860)
- Lynn B. Dustin (ORCID: https://orcid.org/0000-0002-2619-1867)
- Ryan Glass (ORCID: https://orcid.org/0000-0002-8802-7288)
- Audrey Gérard (ORCID: https://orcid.org/0000-0003-3059-3065)
- Gemma Harris (ORCID: https://orcid.org/0000-0002-4587-4620)
- Sarah Hill (ORCID: https://orcid.org/0009-0004-2423-591X)
- Yavuz F. Yazicioglu (ORCID: https://orcid.org/0000-0003-3731-9333)
- Jelena S. Bezbradica (ORCID: https://orcid.org/0000-0003-1441-1727)
- Mark Steven Cragg (ORCID: https://orcid.org/0000-0003-2077-089X)
- Saba Nayar (ORCID: https://orcid.org/0000-0002-4350-110X)
- Joannah R. Fergusson (ORCID: https://orcid.org/0000-0001-9223-1209)
- G.M. Mead
- Marcus Widdess (ORCID: https://orcid.org/0000-0002-2063-8090)
- Esther L. Jones Evans (ORCID: https://orcid.org/0009-0009-1032-650X)
Institutions
- University of Oxford (GB)
- Research Complex at Harwell (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Southampton (GB)
- Quest Diagnostics (United States) (US)
- University of Birmingham (GB)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1126/sciimmunol.ads9680
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Kennedy Trust for Rheumatology Research
- National Institute for Health and Care Research
- Medical Research Council
- Birmingham Biomedical Research Centre