Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein
H]ACI-12589 reported here support the development of additional derivatives and structural scaffolds of asyn-44 with the potential to improve radiotracer specificity and selectivity towards α-syn.
Authors
- Paul McQuade (ORCID: https://orcid.org/0000-0003-0282-0208)
- Ann-Kathrin Grotegerd
- Anna Pees (ORCID: https://orcid.org/0000-0001-8207-3358)
- Robert H. Mach (ORCID: https://orcid.org/0000-0002-7645-2869)
- Gitte M. Knudsen (ORCID: https://orcid.org/0000-0003-1508-6866)
- Ashley C. Knight (ORCID: https://orcid.org/0000-0003-2225-360X)
- Chester A. Mathis (ORCID: https://orcid.org/0000-0001-9811-0950)
- Matthias M. Herth (ORCID: https://orcid.org/0000-0002-7788-513X)
- Neil Vasdev (ORCID: https://orcid.org/0000-0002-2087-5125)
- Giuseppe Cannazza (ORCID: https://orcid.org/0000-0002-7347-7315)
- Cassis Varlow (ORCID: https://orcid.org/0000-0003-1217-764X)
- Daniel Bleher (ORCID: https://orcid.org/0000-0002-2216-2524)
- Junchao Tong (ORCID: https://orcid.org/0000-0001-9299-0045)
- Brian J. Lopresti
- Umberto Maria Battisti (ORCID: https://orcid.org/0000-0002-1012-8644)
- Jeffrey S. Stehouwer (ORCID: https://orcid.org/0000-0001-8871-2544)
- Anton Lindberg (ORCID: https://orcid.org/0000-0002-0076-8517)
- Vladimir Shalgunov (ORCID: https://orcid.org/0000-0001-8956-1207)
- Dinahlee Saturnino Guarino (ORCID: https://orcid.org/0009-0003-3841-1825)
- Merlin Zabrocki
- Kristina Herfert (ORCID: https://orcid.org/0000-0003-0231-7717)
- Arafat Nasser
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Copenhagen (DK)
- Siemens (Germany) (DE)
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Takeda (Japan) (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1177/1877718x261431108
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Ontario Research Foundation
- Centre for Addiction and Mental Health Foundation
- Canada Foundation for Innovation
- Canada Research Chairs
- Azrieli Foundation
- National Institute of Neurological Disorders and Stroke