Rational Design, Synthesis, and Biological Evaluation of Potent, Highly Selective 1,2,4-Oxadiazole-Based S1PR1 Agonists for UC Treatment
as a highly selective and potent S1PR1 agonist with promising potential as a candidate drug for UC treatment.
Authors
- T Ye
- Ranran Wang (ORCID: https://orcid.org/0000-0002-6573-4609)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Zhongping Xu (ORCID: https://orcid.org/0000-0003-2559-9091)
- Yunping Xiao
- Rui Wang
- Jinling Yu
- Luqi Zhang
- Huan He (ORCID: https://orcid.org/0009-0001-9337-097X)
- Chenyang Tang
- Simeng Huang
Institutions
- East China University of Science and Technology (CN)
- Drug Discovery Laboratory (Norway) (NO)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03837
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China