USP18 promotes clear cell renal cell carcinoma progression by regulating the ubiquitination and stability of YBX3

, USP18 deficiency inhibits xenograft tumor growth by decreasing YBX3 expression and blocking the PI3K/AKT pathway. Our findings underscore the therapeutic potential of targeting the USP18-YBX3 axis in ccRCC treatment.

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Publication Details

Journal
iScience
Published
2026-04-17
DOI
https://doi.org/10.1016/j.isci.2026.115808
Primary Topic
Ubiquitin and proteasome pathways
Type
article
Field-Weighted Citation Impact
0.00

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article

USP18 promotes clear cell renal cell carcinoma progression by regulating the ubiquitination and stability of YBX3

Zhijie You, Yihui He, Siqi Chen, Chen Wang et al.
iScience
Ubiquitin and proteasome pathways
article

USP18 promotes clear cell renal cell carcinoma progression by regulating the ubiquitination and stability of YBX3

Zhijie You, Yihui He, Siqi Chen, Chen Wang, Xin Chen
article en

Abstract

, USP18 deficiency inhibits xenograft tumor growth by decreasing YBX3 expression and blocking the PI3K/AKT pathway. Our findings underscore the therapeutic potential of targeting the USP18-YBX3 axis in ccRCC treatment.

iScienceVol. 29(5)
Fujian Medical University (CN), Fujian Provincial Hospital (CN)
Fujian Provincial Hospital
Good health and well-being
Openalex Percentile: Top 25%
Ubiquitin and proteasome pathways
DOIOpen Access PDFOpenAlex
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