Effect of triglyceride levels on bone marrow-derived dendritic cells in sepsis

The potential role of diacylglycerol acyltransferase 1(DGAT1) in regulating dendritic cell (DC) function and apoptosis in sepsis and its associated mechanisms is still unknown. Levels of very low-density lipoproteins (VLDLs), which transport endogenous triglycerides, are elevated in sepsis, leading to hypertriglyceridemia. Triacylglyceride (triacylglycerol, TAG) is the main energy storage material in life. DGAT 1 is a key enzyme in triglyceride synthesis, responsible for TAG synthesis during fat absorption and storage. This study explored the effect of the regulation of DGAT 1 expression on the immune function of dendritic cells in sepsis and associated mechanisms. Downregulation of DGAT 1 expression improved the function and apoptosis of bone marrow-derived dendritic cells in sepsis and may have activated pathway signaling proteins (JAK 2 and STAT 3) to alleviate oxidative stress and inflammation. These suggest that DGAT 1 may have a role in improving immune function in sepsis.