Albumin Nanoparticles Improve Colistin Performance Against Hetero- and Full-Resistant Clinical A. baumannii: A Mechanistic Study
isolates, with particularly strong effects in heteroresistant strains. The combined effects of PMF modulation, increased intracellular drug availability, and envelope interaction provide a mechanistic rationale for the use of albumin-based nanoparticles, either as Col carriers or in combination with free drug, to overcome Col resistance and heteroresistance.
Authors
- Eleonora Chines
- Gabriele Bianco (ORCID: https://orcid.org/0000-0002-8180-5075)
- Roberta Cavalli (ORCID: https://orcid.org/0000-0002-2600-0661)
- Matteo Florio Furno (ORCID: https://orcid.org/0000-0001-6483-3886)
- Monica Argenziano (ORCID: https://orcid.org/0000-0002-8485-7460)
- Tiziana Musso (ORCID: https://orcid.org/0000-0002-7487-6078)
- Viviana Cafiso (ORCID: https://orcid.org/0000-0002-0785-7934)
- Sara Scutera (ORCID: https://orcid.org/0000-0002-7431-0875)
- Giovanna Cristina Varese (ORCID: https://orcid.org/0000-0002-1455-6208)
- Antonio Curtoni (ORCID: https://orcid.org/0000-0001-8101-4196)
- Chiara Scarpa
- Stefania Raimondo (ORCID: https://orcid.org/0000-0002-8907-473X)
- Ilario Ferrocino (ORCID: https://orcid.org/0000-0002-1657-0054)
- Giulia Vigna (ORCID: https://orcid.org/0000-0002-5405-0922)
Institutions
- University of Salento (IT)
- University of Pavia (IT)
- University of Catania (IT)
- Neuroscience Institute (IT)
- University of Turin (IT)
Publication Details
- Journal
- Antibiotics
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/antibiotics15040410
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cetacean Research Technology
- European Commission
- Università degli Studi di Torino