Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes
Dairy cow health involves host-microbiome interactions. This review characterized microbial landscapes across anatomical sites in dairy cows-including the gastrointestinal tract, respiratory system, reproductive tract, mammary gland, and skin-and examines their associations with diseases. We elucidated how site-specific dysbiosis drives systemic conditions such as mastitis and ketosis through inter-organ axes. Finally, we evaluated emerging microbiome-based modulation strategies and their application prospects in dairy farming.
Authors
- Ao Ren (ORCID: https://orcid.org/0000-0002-0099-7256)
- Yanliang Bi (ORCID: https://orcid.org/0000-0001-8183-8208)
- Naifeng Zhang
- Yan Tu
- Cheng Guo
- Junwei Cui
- Pei Zhong
- Qiyu Diao
- Xianjun Liu
- Yanmei Zhang
Institutions
- Shenyang Agricultural University (CN)
- Ningxia University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Feed Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- npj Biofilms and Microbiomes
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1038/s41522-026-00988-8
- Primary Topic
- Milk Quality and Mastitis in Dairy Cows
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China