Bisphosphonate Pamidronate for Treatment of Complex Regional Pain Syndrome Type I: A Systematic Review and Meta-Analysis

= 88%) and a wide prediction interval (-19.257 to 20.701), highlighting high uncertainty and the need for cautious interpretation due to the limited studies. Intravenous pamidronate may offer symptom relief for individuals with CRPS I, particularly in reducing pain and edema and improving function. Given the heterogeneity of the studies and limited sample sizes, findings should be interpreted as preliminary and hypothesis-generating rather than definitive.