Linear associations of triglyceride-glucose body mass index and atherogenic index of plasma with the risk of diabetes: a retrospective cohort study

Background: This research intends to examine the relationship between triglyceride glucose-body mass index (TyG-BMI) and the Atherogenic Index of Plasma (AIP) in relation to the risk of diabetes, as well as evaluate their predictive capabilities. Methods: This retrospective cohort study included data from 116,662 Chinese adults with normal baseline glucose levels. Participants were categorized according to tertiles of triglyceride-glucose body mass index (TyG-BMI; TT1-TT3) and atherogenic index of plasma (AIP; TA1-TA3), as well as nine combined categories (TC1-TC9). Incident diabetes mellitus (DM) was assessed after a mean follow-up of 37.4 months, and the primary endpoint was new-onset DM. Results: < 0.001). Conclusions: In this Chinese adult cohort, TyG-BMI and AIP were significantly associated with incident DM and showed added predictive value. Incorporating TyG-BMI, AIP, or their combination into the baseline risk model significantly improved diabetes risk prediction.