Tuning Selectivity in Reductive Amination Through Orbital Symmetry Engineering of Metal‐Organic Supports
unit, which weakens the adsorption and activation of Schiff base intermediates, thereby kinetically retarding their further ammonolysis. Our work establishes a paradigm for controlling catalytic selectivity through picoscale orbital symmetry manipulation at support metal sites.
Authors
- Caoyu Yang (ORCID: https://orcid.org/0000-0003-0687-4270)
- Zhiyong Tang (ORCID: https://orcid.org/0000-0003-0610-0064)
- Siyang Li (ORCID: https://orcid.org/0000-0001-9475-6869)
- Huiwen Gao (ORCID: https://orcid.org/0000-0002-6559-4634)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
Institutions
- National Center for Nanoscience and Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1002/anie.8403490
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China