Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brain
protein product in a manner that has widespread effects on gene expression in the brain and supports the hypothesis that these haplotypes may influence AD risk and pathogenesis.
Authors
- Kevin P. Kotredes (ORCID: https://orcid.org/0000-0001-7874-4139)
- Dylan Garceau
- Christoph Preuß (ORCID: https://orcid.org/0000-0003-1039-6080)
- Catrina Spruce
- Anna L. Tyler (ORCID: https://orcid.org/0000-0001-8371-2377)
- Annat Haber (ORCID: https://orcid.org/0000-0001-8407-9171)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Gregory W Carter
Institutions
- Jackson Laboratory (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-16
- DOI
- https://doi.org/10.64898/2026.04.15.718745
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health