Mesoscopic Fluorescence Imaging of Light-Triggered Chemotherapeutic Release in Cancer Spheroid Models
These results support a quantitative imaging framework for fluorescence-guided monitoring of light-triggered liposomal drug release and may enable individualized CPT dosimetry for peritoneal micrometastases. Findings in SCC2095sc additionally suggest potential relevance of fluorescence-guided CPT for head and neck/oral cancer, where localized post-resection adjuvant treatment may improve control of residual disease.
Authors
- Jonathan F. Lovell (ORCID: https://orcid.org/0000-0002-9052-884X)
- Hilliard L. Kutscher (ORCID: https://orcid.org/0000-0003-4779-2132)
- Ulaş Sunar (ORCID: https://orcid.org/0000-0002-0623-7522)
- Matthew Willadsen
- Berna Aliu
- Elias Kluiszo (ORCID: https://orcid.org/0009-0002-4064-8699)
- Semra Aygun-Sunar
- Rasel Ahmmed
Institutions
- Stony Brook University (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/pharmaceutics18040495
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ohio State University
- Stony Brook University
- National Institutes of Health
- National Cancer Institute