(5R)-5-Hydroxytriptolide (LLDT-8) Ameliorates Experimental Autoimmune Myositis via Suppression of the NLRC5/MHC-I Signaling Pathway
LLDT-8 alleviates inflammatory muscle injury by targeting the NLRC5/MHC-I signaling axis, suggesting it may be a promising therapeutic candidate for IIMs.
Authors
- Cancan Xie
- Jianping Zuo
- 何时军
- Qing Qi (ORCID: https://orcid.org/0000-0001-9347-3525)
- Fenghua Zhu
- Tingting Hao
- Meijuan Shao
- Zemin Lin (ORCID: https://orcid.org/0000-0002-3665-874X)
- Xiaoqian Yang
- Li Chen
- Que Wang
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Wuhan Business University (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/ph19040631
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Natural Science Foundation of Hubei Province