Anchorage‐independent and faster growth in clonal population from <scp>UV</scp> ‐irradiated <scp>NER</scp> ‐deficient cells
, exhibit behaviours typically associated with tumour heterogeneity. Specifically, these clones show anchorage-independent growth, differences in cell cycle regulation, frequency of atypical mitoses, expression of oncogenes and tumour suppressors and resistance to cisplatin treatment. Taken together, these findings highlight the critical role of DDB2-PCNA interaction in maintaining genome stability and preventing cellular transformation.
Authors
- Ornella Cazzalini (ORCID: https://orcid.org/0000-0003-2113-4158)
- Paola Perucca (ORCID: https://orcid.org/0000-0002-7821-0388)
- Lucia Anna Stivala (ORCID: https://orcid.org/0000-0003-3591-2950)
- Ennio Prosperi (ORCID: https://orcid.org/0000-0001-5391-5157)
- Anna Tricarico
- Martina Furfaro
- Priyam Ghosh
Institutions
- University of Pavia (IT)
- Istituto di Genetica Molecolare (IT)
Publication Details
- Journal
- FEBS Open Bio
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1002/2211-5463.70195
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero dell'Università e della Ricerca