Activating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival

ARTICLE HIGHLIGHTS: The role of activating transcription factor 6α (ATF6α) in the stress-adaptive regulation of pancreatic β-cell mass (BCM) in vivo remains incompletely defined. We investigated the role of ATF6α in the regulation of BCM, β-cell proliferation, and survival under sustained stress using in vivo and in vitro models. Loss of ATF6α consistently impaired BCM expansion through reduced β-cell proliferation and increased apoptosis across models. Our findings establish ATF6α as an important regulator of stress-adaptive BCM expansion through coordinating β-cell survival and proliferation under sustained stress.

Authors

Institutions

Publication Details

Journal
Diabetes
Published
2026-04-17
DOI
https://doi.org/10.2337/db26-0048
Primary Topic
Pancreatic function and diabetes
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Activating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival

Sho Sekito, Daisuke Otani, Ryota Usui, Ainur Botagarova et al.
Diabetes
Pancreatic function and diabetes
article

Activating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival

Sho Sekito, Daisuke Otani, Ryota Usui, Ainur Botagarova, Takaaki Murakami, Shinsuke Tokumoto, Nobuya Inagaki, Daisuke Yabe, Hisato Tatsuoka, Masahito Ogura, Yasuhiro Murakawa, Muhammad Fauzi, Taro Toyoda
article en

Abstract

ARTICLE HIGHLIGHTS: The role of activating transcription factor 6α (ATF6α) in the stress-adaptive regulation of pancreatic β-cell mass (BCM) in vivo remains incompletely defined. We investigated the role of ATF6α in the regulation of BCM, β-cell proliferation, and survival under sustained stress using in vivo and in vitro models. Loss of ATF6α consistently impaired BCM expansion through reduced β-cell proliferation and increased apoptosis across models. Our findings establish ATF6α as an important regulator of stress-adaptive BCM expansion through coordinating β-cell survival and proliferation under sustained stress.

Diabetes
Mie University (JP), Kyoto University (JP), Kyoto Medical Center (JP), KRI (JP), Kansai Electric Power Hospital (JP), RIKEN Center for Integrative Medical Sciences (JP), Kitano Hospital (JP)
Takeda Science Foundation, Japan Foundation for Applied Enzymology, Uehara Memorial Foundation, Japan Association for Diabetes Education and Care, Fujiwara Memorial Foundation, Japan IDDM network, Japan Diabetes Society, Japan Diabetes Foundation, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 14%
Pancreatic function and diabetes
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.