Insular glioma and emotional states affect the whole brain network: a task-state electroencephalography study

Purpose: This study investigated the effects of insular gliomas on brain functional network dynamics during auditory stimulus processing via task-state electroencephalography (EEG) combined with graph theory analysis. Methods: ) across four frequency bands. Neuropsychological assessments (MoCA, MMSE, HAMA, HDRS) were performed to evaluate cognitive and emotional states. Results: > 0.05 for left). Conclusion: Insular gliomas impair beta band whole brain functional network integration and small-worldness under novel stimuli, with prominent hemispheric specificity: right insular glioma patients show significant topological indicator damage, while left insular glioma patients maintain stable networks via left dominant hemisphere interhemispheric compensatory plasticity. Beta band Cp, locE and small-worldness coefficient under novel stimuli are potential neurophysiological indicators for insular glioma assessment, especially for right insular lesions. These indices are closely associated with anxiety and depression in right insular glioma patients, highlighting the need to consider tumor laterality in clinical evaluation and implement comprehensive emotional interventions for such patients.