Thionyl Chloride-Mediated Synthesis of Erlenmeyer Azlactones from <i>N</i> -Acylated α-Amino Acids
-acylated phenylalanine derivatives as well as selected aliphatic and aromatic amino acids. Control experiments highlight the unique role of thionyl chloride in promoting the cyclization. This protocol provides a straightforward route to azlactone scaffolds from readily available amino acid precursors.
Authors
- Abed Saady (ORCID: https://orcid.org/0000-0002-6142-2376)
- Arjun Veliyil Prakash
- Hajar Aledwan
- Guy Zimmermann
- Natalia Fridman
Institutions
- Bar-Ilan University (IL)
- Technion – Israel Institute of Technology (IL)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.joc.6c00508
- Primary Topic
- Synthesis and Reactions of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bar-Ilan University
- Council for Higher Education