Inflammation-Driven JNK Activation Promotes EMT and Metastasis in Gastric Cancer and Is Attenuated by Huangjin Shuangshen Granules
HJSS suppresses inflammation-driven GC metastasis primarily by attenuating JNK-associated EMT, potentially through modulation of JNK activation by its bioactive constituents. These findings provide mechanistic insight into HJSS as a low-toxicity anti-metastatic strategy and support further exploration of its active constituents.
Authors
- Jingan Lou (ORCID: https://orcid.org/0000-0001-9142-5378)
- Zhiyuan Song
- Sicheng Zhao (ORCID: https://orcid.org/0000-0002-9018-6958)
- Shuo Zhang (ORCID: https://orcid.org/0009-0005-1096-7148)
- Jingcheng Zhang
- Chen Huang
- Guangji Zhang
- Tao Jiang
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/ph19040636
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China