Simultaneous Induction of Ferroptosis and Immunogenic Cell Death by TrxR-Targeted Pt(IV) Prodrugs for Chemoimmunotherapy of Triple-Negative Breast Cancer

induced an excessive accumulation of intracellular reactive oxygen species to trigger endoplasmic reticulum (ER) stress and subsequently induce immunogenic cell death. Overall, this study presents an innovative strategy for enhancing cisplatin sensitivity and overcoming cisplatin resistance in TNBC through the use of dual-targeted TrxR and DNA Pt(IV) prodrugs, thereby offering a new approach to treating TNBC.