An Inducible hiPSC-Derived Human Podocyte Model for Functional Analysis of TRPC6 Variants Associated with FSGS
agonists and antagonists. Our data showed relative calcium responses consistent with the GoF and LoF phenotypes. Transgenic iPSC-based models, like the one presented here, are instrumental to studying disease mechanisms in vitro and investigating the outcomes of, and possible therapeutic interventions for, this complex disease.
Authors
- Manfred Gossen (ORCID: https://orcid.org/0000-0002-1761-4063)
- Krithika Hariharan (ORCID: https://orcid.org/0000-0001-6172-9602)
- Gabriel Stölting (ORCID: https://orcid.org/0000-0002-2339-0545)
- Lilas Batool (ORCID: https://orcid.org/0000-0002-9241-1485)
- Dimitry Tsvetkov
- Andreas Kurtz (ORCID: https://orcid.org/0000-0003-3301-6546)
- Tingting Zhong
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Helmholtz-Zentrum Hereon (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cells
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/cells15080712
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Einstein Stiftung Berlin
- Berlin-Brandenburg School for Regenerative Therapies
- Stiftung der Deutschen Wirtschaft
- Berlin Institute of Health
- Einstein Centrum für Regenerartive Therapien, Charité-Universitätsmedizin Berlin