Discovery of Dual-Target Anti-Alzheimer’s Filicinic Acid-Based Meroterpenoids from <i>Hypericum japonicum</i> Thunb.
acts as a dual-target agent by both activating PPARγ and inhibiting BACE1, highlighting its potential as a novel therapeutic candidate for Alzheimer's disease.
Authors
- Jingyu Sun (ORCID: https://orcid.org/0000-0002-9812-3046)
- Shengfei Zhong
- 何守伦
- Yuhang You
- Lulu Fu (ORCID: https://orcid.org/0000-0002-8667-5126)
- J Chen
- Xiaobin Li (ORCID: https://orcid.org/0000-0002-3775-7694)
- Yuxin Lin
- Guanghui Wang
- Haifeng Chen (ORCID: https://orcid.org/0000-0002-8181-7893)
Institutions
- Target (United States) (US)
- Qilu University of Technology (CN)
- Xiamen University (CN)
- Shandong Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00131
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province