Single-cell RNA sequencing unravels T cell exhaustion underlying the chronicity of chromoblastomycosis
Introduction: Chromoblastomycosis (CBM) is a chronic, neglected tropical fungal infection. Its immunopathogenesis, particularly the mechanism underlying its chronicity, remains poorly understood. Methods: infection. Results: infection. Discussion: T cell exhaustion as an important mechanism underlying the chronicity of chromoblastomycosis, revealing a new immunopathological perspective for this neglected disease.
Authors
- Zhuoqing Gong (ORCID: https://orcid.org/0000-0003-1020-793X)
- Kexin Lei (ORCID: https://orcid.org/0000-0001-8778-5506)
- Zhe Wan (ORCID: https://orcid.org/0000-0001-8088-1677)
- Jie Tian (ORCID: https://orcid.org/0000-0003-0498-0432)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Bilin Dong
- Xiaowen Wang
- Lu Zhang
- Wenjie Liu
- Ruoyu Li
Institutions
- National Skin Centre (SG)
- Peking University (CN)
- SKiN Health (CA)
- Innovative Clinical Research (US)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3389/fimmu.2026.1784450
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00