Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge
platform enables targeted delivery of biologics to the lung, modulates the lung environment, and improves pathology without inducing systemic immune reactions.
Authors
- Stéphanie Humblet‐Baron (ORCID: https://orcid.org/0000-0003-4684-069X)
- Ntombizodwa Makuyana (ORCID: https://orcid.org/0009-0004-8275-1162)
- Lauren Michiels (ORCID: https://orcid.org/0009-0001-7588-4694)
- Amy Dashwood (ORCID: https://orcid.org/0000-0002-4340-377X)
- Ekhlas Rahman (ORCID: https://orcid.org/0009-0006-8940-2920)
- Oliver T. Burton (ORCID: https://orcid.org/0000-0003-3884-7373)
- Stéphane M. Guillaume (ORCID: https://orcid.org/0000-0003-2007-4608)
- Joost Wauters (ORCID: https://orcid.org/0000-0002-5983-3897)
- Michelle A. Linterman (ORCID: https://orcid.org/0000-0001-6047-1996)
- Lubna Kouser (ORCID: https://orcid.org/0000-0002-3592-7768)
- Greetje Vande Velde (ORCID: https://orcid.org/0000-0002-5633-3993)
- K. N. Singh (ORCID: https://orcid.org/0000-0002-6771-7757)
- Stéphanie Liénart (ORCID: https://orcid.org/0000-0002-5825-6979)
- Lieve M. J. Naesens (ORCID: https://orcid.org/0000-0001-9742-9302)
- Régis Joulia (ORCID: https://orcid.org/0000-0002-7908-5670)
- Adrian Liston (ORCID: https://orcid.org/0000-0002-6272-4085)
- Laura Seldeslachts (ORCID: https://orcid.org/0000-0002-9562-2923)
- Magda Ali (ORCID: https://orcid.org/0009-0005-1260-7808)
- Arman Ghodsinia
- Alvaro R. Hernandez
- Marwane Achkir (ORCID: https://orcid.org/0009-0008-1367-9039)
- Laura M. Kops (ORCID: https://orcid.org/0009-0009-6427-4493)
- Fran Naranjo
Institutions
- Uppsala University (SE)
- Babraham Institute (GB)
- MRC Laboratory of Molecular Biology (GB)
- Malaghan Institute of Medical Research (NZ)
- University of Cambridge (GB)
- Imperial College London (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1126/sciimmunol.adv7969
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Fonds Wetenschappelijk Onderzoek
- Gates Cambridge Trust
- Wallonie-Bruxelles International
- Vlaamse regering
- H2020 European Research Council