Editorial: Exploring miRNA roles in cancer pathogenesis and treatment, volume III

they function as oncogenes or tumor suppressors to shape tumor initiation, progression, metastasis, and therapy resistance. Owing to their stability in tissues and body fluids, miRNAs have also emerged as promising biomarkers and therapeutic targets (Calin and Croce 2006). Collectively, these contributions highlight miRNAs as central regulators linking signaling pathways, epigenetic control, and tumor behavior. Advances in highthroughput sequencing and bioinformatics continue to accelerate the identification and functional characterization of miRNAs, while their utility as minimally invasive biomarkers and therapeutic targets is rapidly expanding (Rupaimoole and Slack 2017).Despite this progress, several challenges remain, including limited delivery efficiency, potential off-target effects, and the context-dependent functions of individual miRNAs within complex regulatory networks. Addressing these barriers will be essential for translating miRNA-based strategies into clinical applications.Overall, this Research Topic underscores the expanding role of miRNAs in cancer biology and highlights their potential to drive next-generation diagnostic and therapeutic innovations in precision oncology.