Chemico-biological evaluation of carpachromene against key antimicrobial protein targets: an integrated in-silico, in-vitro approach for mechanistic insights

Ethnopharmacological Relevance: L. is a prized medicinal plant from the Kashmir Himalaya traditionally utilized to treat many ailments, yet its active metabolites against antimicrobial mechanisms remain unclear. Aim of the Study: . Materials and Methods: MTCC343), evaluating concentration-dependent inhibition zones relative to standard controls (ciprofloxacin for bacteria; fluconazole for fungi). Results: . Conclusion: observations, highlighting carpachromene as a promising multi-target antimicrobial scaffold. These findings support supradecoration strategies for advancing carpachromene toward novel drug development against antimicrobial resistance.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-04-17
DOI
https://doi.org/10.3389/fphar.2026.1785267
Primary Topic
Bioactive natural compounds
Type
article
Field-Weighted Citation Impact
0.00

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article

Chemico-biological evaluation of carpachromene against key antimicrobial protein targets: an integrated in-silico, in-vitro approach for mechanistic insights

Venkatramanan Varadharajan, Masood Ahmad Rizvi, Ibraq Khurshid, Basharat Ahmad Bhat et al.
Frontiers in Pharmacology
Bioactive natural compounds
article

Chemico-biological evaluation of carpachromene against key antimicrobial protein targets: an integrated in-silico, in-vitro approach for mechanistic insights

Venkatramanan Varadharajan, Masood Ahmad Rizvi, Ibraq Khurshid, Basharat Ahmad Bhat, Aarif Nazir, Ishteyaq Majeed Shah, Mushtaq A. Mir, Nasreena Bashir, Fayaz Ahmad, Shaista Masarat
article en

Abstract

Ethnopharmacological Relevance: L. is a prized medicinal plant from the Kashmir Himalaya traditionally utilized to treat many ailments, yet its active metabolites against antimicrobial mechanisms remain unclear. Aim of the Study: . Materials and Methods: MTCC343), evaluating concentration-dependent inhibition zones relative to standard controls (ciprofloxacin for bacteria; fluconazole for fungi). Results: . Conclusion: observations, highlighting carpachromene as a promising multi-target antimicrobial scaffold. These findings support supradecoration strategies for advancing carpachromene toward novel drug development against antimicrobial resistance.

Frontiers in PharmacologyVol. 17
University of Kashmir (IN), Department of Biotechnology (IN), Cluster University Srinagar (IN), Department of Mathematical Sciences (RU), Central University of Kashmir (IN), King Khalid University (SA)
King Khalid University
Openalex Percentile: Top 20%
Bioactive natural compounds
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