Chemico-biological evaluation of carpachromene against key antimicrobial protein targets: an integrated in-silico, in-vitro approach for mechanistic insights
Ethnopharmacological Relevance: L. is a prized medicinal plant from the Kashmir Himalaya traditionally utilized to treat many ailments, yet its active metabolites against antimicrobial mechanisms remain unclear. Aim of the Study: . Materials and Methods: MTCC343), evaluating concentration-dependent inhibition zones relative to standard controls (ciprofloxacin for bacteria; fluconazole for fungi). Results: . Conclusion: observations, highlighting carpachromene as a promising multi-target antimicrobial scaffold. These findings support supradecoration strategies for advancing carpachromene toward novel drug development against antimicrobial resistance.
Authors
- Venkatramanan Varadharajan
- Masood Ahmad Rizvi (ORCID: https://orcid.org/0000-0003-0470-6329)
- Ibraq Khurshid
- Basharat Ahmad Bhat (ORCID: https://orcid.org/0000-0002-4847-4825)
- Aarif Nazir
- Ishteyaq Majeed Shah
- Mushtaq A. Mir
- Nasreena Bashir
- Fayaz Ahmad
- Shaista Masarat
Institutions
- University of Kashmir (IN)
- Department of Biotechnology (IN)
- Cluster University Srinagar (IN)
- Department of Mathematical Sciences (RU)
- Central University of Kashmir (IN)
- King Khalid University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3389/fphar.2026.1785267
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Khalid University