TREM2 in age-related macular degeneration: a microglia-centered perspective in the retinal myeloid landscape
. Here, we synthesize current evidence on retinal myeloid contributions to dry and neovascular AMD, provide an updated mechanistic framework for TREM2 signaling, and discuss therapeutic strategies and translational challenges for targeting TREM2 in AMD.
Authors
- Taoshuo Yang
- Lei Shi
- Shengyu Zhu
- Limei Sheng
Institutions
- Yangzhou Vocational University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
- University of Glasgow (GB)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Ophthalmology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3389/fopht.2026.1804578
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00