Effects of AGK-2 treatment on sirtuin-2, oxidative stress and apoptosis in ageing pancreatic tissue of rats
: Our findings showed that ageing increased SIRT2 expression, oxidative stress and caspase-3 protein compared to young rats. AGK-2 treatment reduced SIRT2, TOS, OSI and caspase-3, and increased TAS particularly in aged rats. AGK-2 reverses ageing-associated changes in pancreatic oxidative stress and apoptosis. SIRT2 modulation may represent a potential therapeutic target against age-related pancreatic degeneration.
Authors
- Arzu Keskin Aktan (ORCID: https://orcid.org/0000-0002-2878-0841)
- Cansu Babahan (ORCID: https://orcid.org/0000-0002-6806-1091)
- K. Gonca AKBULUT
- Saide Bakal Muratoğlu
Institutions
- Ankara University (TR)
- Gazi Hastanesi (TR)
- Yüksek İhtisas Üniversitesi (TR)
- Afyon Kocatepe University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Archives of Physiology and Biochemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1080/13813455.2026.2657419
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00