FOXP-stabilization of the <i>Il2ra</i> super-enhancer structure augments Treg fitness
locus in mature Tregs, augment super-enhancer activity, and drive sustained CD25 expression. Our results reveal a unique role of FOXP1, and to a lesser extent FOXP4, in controlling Treg homeostasis.
Authors
- Yesl Kim (ORCID: https://orcid.org/0000-0001-7749-641X)
- Jiayan Zhou (ORCID: https://orcid.org/0000-0001-5974-087X)
- Warren J. Leonard (ORCID: https://orcid.org/0000-0002-5740-7448)
- Jian-Xin Lin (ORCID: https://orcid.org/0000-0001-5849-9412)
- Jonathan S. Maltzman (ORCID: https://orcid.org/0000-0001-5722-269X)
- Jyothi Padiadpu (ORCID: https://orcid.org/0000-0002-9507-6133)
- Dachuan Dong (ORCID: https://orcid.org/0000-0002-5443-5304)
- Lauren E. Higdon (ORCID: https://orcid.org/0000-0002-6470-6155)
Institutions
- Palo Alto University (US)
- VA Palo Alto Health Care System (US)
- Palo Alto Veterans Institute for Research (US)
- National Heart, Lung, and Blood Institute (US)
- Geriatric Research Education and Clinical Center (US)
- Stanford University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-17
- DOI
- https://doi.org/10.64898/2026.04.14.718220
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00