A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use
depletion. Silencing noradrenergic neurons or astroglial signaling abolished these hypoxia coping behaviors, whereas selective activation evoked them. This neuronal-astroglial mechanism constitutes a predictive control system that integrates physiological state with behavioral intent to avert metabolic crisis, revealing a cellular substrate for proactive energy management.
Authors
- Javier J. How (ORCID: https://orcid.org/0000-0002-9952-9304)
- Michele Nardin (ORCID: https://orcid.org/0000-0001-8849-6570)
- W S Chen
- Behtash Babadi (ORCID: https://orcid.org/0000-0002-9856-006X)
- RongWei Zhang
- Jing-Xuan Lim (ORCID: https://orcid.org/0000-0002-5983-9164)
- David A. Prober (ORCID: https://orcid.org/0000-0002-7371-4675)
- Martin Haesemeyer (ORCID: https://orcid.org/0000-0003-2704-3601)
- Florian Engert (ORCID: https://orcid.org/0000-0001-8169-2990)
- Sujatha Narayan (ORCID: https://orcid.org/0000-0002-3741-1319)
- Virginia M. S. Ruetten (ORCID: https://orcid.org/0000-0003-0073-2861)
- Jiulin Du
- Misha B. Ahrens
- Brett D. Mensh
- Mark C. Fishman
- Ziqiang Wei
- Anuththara Rupashinge
- Amina Kinkhabwala
Institutions
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Neurosciences Institute (US)
- Janelia Research Campus (US)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Applied Physics (CN)
- Harvard Stem Cell Institute (US)
- The Ohio State University (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-14
- DOI
- https://doi.org/10.64898/2026.04.10.717666
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00