Stereochemical Aspects in the Context of the Structure–Activity Relationship of Chlorido[ <i>N</i> , <i>N</i> ′-bis(chloro/bromosalicylidene)-1,2-diphenyl-1,2-diaminoethane]iron(III) Complexes
caused extensive lipid oxidation and ferroptosis as part of the mode of action. Exchange of the 3-Cl substituents for 3-Br only marginally changed the biological effects, whereas the introduction of 3-Br, 5-Cl substituents led to a loss of activity. The differences in effectiveness result from the spatial structure caused by the 1,2-diphenylethane skeleton.
Authors
- Stephan Hohloch (ORCID: https://orcid.org/0000-0002-5353-0801)
- Brigitte Kircher (ORCID: https://orcid.org/0000-0003-1624-2664)
- Ronald Gust (ORCID: https://orcid.org/0000-0002-0427-4012)
- Mostafa Alilou (ORCID: https://orcid.org/0000-0002-5068-6720)
- Astrid Dagmar Bernkop-Schnürch
- Daniel Leitner (ORCID: https://orcid.org/0000-0002-1470-9761)
- Sofie Hanifle
- Martin Hermann
- Michael Seidl
- Stefanie Schwarz
- Philipp Rigo
- Magnus Andre Kiechle
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Tyrolean Cancer Research Institute (AT)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03253
- Primary Topic
- Metal-Catalyzed Oxygenation Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund