Slow Dissociation of Nitazenes from the <i>μ</i> -Opioid Receptor Underlies the Challenge of Overdose Reversal
OR signaling bias. Our findings suggest slow receptor dissociation as a key factor challenging overdose reversal. The mechanistic insights have implications for understanding opioid toxicity and designing more effective countermeasures.
Authors
- Laura B. Kozell (ORCID: https://orcid.org/0000-0003-3059-2046)
- Atheir I. Abbas (ORCID: https://orcid.org/0000-0002-7080-3509)
- Lidiya Stavitskaya (ORCID: https://orcid.org/0000-0002-6307-2314)
- Joseph Clayton (ORCID: https://orcid.org/0000-0002-2652-5994)
- Shelley H. Bloom
- Amy J. Eshleman (ORCID: https://orcid.org/0000-0001-7030-557X)
- William E. Schutzer
- Jana Shen (ORCID: https://orcid.org/0000-0002-3234-0769)
Institutions
- University of Maryland, Baltimore (US)
- Center for Drug Evaluation and Research (US)
- Oregon Health & Science University (US)
- VA Portland Health Care System (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-16
- DOI
- https://doi.org/10.64898/2026.04.14.718203
- Primary Topic
- Chemical Reactions and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- National Institutes of Health
- Oak Ridge Institute for Science and Education