Historical and contemporary genomes of an endangered rodent reveal shifts in environmentally associated genes

). Using whole-genome sequences spanning nearly a century, we identify 14 candidate genes associated with temperature and moisture, including many with vascular and circulatory functions. Using a reintroduced population, we find more alleles than expected by chance shifted toward the frequencies predicted for the climate of the reintroduction locality. Despite extreme population declines over the past century, these findings indicate that conservation breeding and reintroduction have retained genetic variation relevant to adaptive potential in the Pacific pocket mouse.