Fractional-order differential model for knee implant recovery in smart health infrastructures

Recovery from knee replacement surgery in conventional orthopaedic healthcare systems can be delayed due to high costs, pain, limited monitoring, and insufficient follow-up, which may hinder early detection of poor healing and inflammation. This study presents a smart orthopaedic healthcare model for knee replacement recovery, where integrated sensors support continuous monitoring and improve the rehabilitation process, thereby reducing delays associated with traditional care systems. A mathematical modelling approach based on compartmental modelling and fractional-order dynamics is used to represent delayed healing responses following total knee replacement surgery. The analysis shows that prolonged delays in monitoring and treatment can lead to unstable recovery patterns, resulting in fluctuations in knee function and inflammation levels. To improve recovery outcomes, the study demonstrates that intelligent sensing devices providing real-time feedback effectively reduce inflammation and enhance joint performance. Results show that when delays are minimised, near-complete restoration of knee function is achieved (≥ 98%), accompanied by optimal inflammation suppression and functional recovery. However, in the presence of delays, recovery remains substantially improved, particularly in terms of inflammation control (≈ 92%), although overall functional gains and recovery efficiency are comparatively reduced. Overall, this work highlights the importance of early inflammation management and feedback-assisted rehabilitation in maintaining knee stability and accelerating recovery. The proposed model provides a theoretical foundation for developing advanced rehabilitation strategies and intelligent device-assisted therapies in smart orthopaedic healthcare systems.

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Publication Details

Journal
Scientific Reports
Published
2026-04-17
DOI
https://doi.org/10.1038/s41598-026-48965-7
Primary Topic
Total Knee Arthroplasty Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Fractional-order differential model for knee implant recovery in smart health infrastructures

Kelvin Anoh, Titus Ifeanyi Chinebu, Juliet Onyinye Nwigwe, Kennedy Chinedu Okafor et al.
Scientific Reports
Total Knee Arthroplasty Outcomes
article

Fractional-order differential model for knee implant recovery in smart health infrastructures

Kelvin Anoh, Titus Ifeanyi Chinebu, Juliet Onyinye Nwigwe, Kennedy Chinedu Okafor, Cajetan Uwatoronye Nwadinigwe, Okafor Ijeoma Peace, Diovu Remigius Chidiebere, Omowunmi Mary Longe
article en

Abstract

Recovery from knee replacement surgery in conventional orthopaedic healthcare systems can be delayed due to high costs, pain, limited monitoring, and insufficient follow-up, which may hinder early detection of poor healing and inflammation. This study presents a smart orthopaedic healthcare model for knee replacement recovery, where integrated sensors support continuous monitoring and improve the rehabilitation process, thereby reducing delays associated with traditional care systems. A mathematical modelling approach based on compartmental modelling and fractional-order dynamics is used to represent delayed healing responses following total knee replacement surgery. The analysis shows that prolonged delays in monitoring and treatment can lead to unstable recovery patterns, resulting in fluctuations in knee function and inflammation levels. To improve recovery outcomes, the study demonstrates that intelligent sensing devices providing real-time feedback effectively reduce inflammation and enhance joint performance. Results show that when delays are minimised, near-complete restoration of knee function is achieved (≥ 98%), accompanied by optimal inflammation suppression and functional recovery. However, in the presence of delays, recovery remains substantially improved, particularly in terms of inflammation control (≈ 92%), although overall functional gains and recovery efficiency are comparatively reduced. Overall, this work highlights the importance of early inflammation management and feedback-assisted rehabilitation in maintaining knee stability and accelerating recovery. The proposed model provides a theoretical foundation for developing advanced rehabilitation strategies and intelligent device-assisted therapies in smart orthopaedic healthcare systems.

Scientific Reports
University of Chichester (GB), University of Nigeria (NG), Manchester Metropolitan University (GB), Federal Ministry of Health (NG), University of Johannesburg (ZA), Imperial College London (GB), Cardiff Metropolitan University (GB)
IEEE Foundation, University of Chichester, Manchester Metropolitan University
Industry, innovation and infrastructure
Openalex Percentile: Top 16%
Total Knee Arthroplasty Outcomes
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