Shared Epitope-Positive <i>HLA</i> Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease
BACKGROUND AND OBJECTIVE: can modulate PD pathology in vivo. METHODS: allele. We then performed a comprehensive histopathologic and molecular characterization of the main disease phenotypes by combining quantitative histopathology, RNA-sequencing, flow cytometry immunophenotyping, and cytokine profiling. RESULTS: mice is in an activated steady state, possibly suggesting their mechanistic involvement in alpha-synuclein clearance. DISCUSSION: allele against alpha-synuclein pathology.
Authors
- Marcelo Fernández-Viña (ORCID: https://orcid.org/0000-0002-5707-2588)
- Jill A. Hollenbach (ORCID: https://orcid.org/0000-0001-6572-7962)
- Alessandro Didonna (ORCID: https://orcid.org/0000-0001-7510-9658)
- Joseph Holoshitz (ORCID: https://orcid.org/0000-0002-6563-0404)
- Bryce A. Pugh (ORCID: https://orcid.org/0009-0001-2746-4206)
- Jonathan J. Carver
- A Puckett
- Jorge Oksenberg
- Stacy J. Caillier
- Qin Ma
- Taylor C. Roberson (ORCID: https://orcid.org/0009-0006-2943-447X)
- Cindy C. Martines (ORCID: https://orcid.org/0009-0000-9937-9038)
- Rachael R. Denbrock (ORCID: https://orcid.org/0009-0008-3072-4903)
Institutions
- Palo Alto University (US)
- University of California, San Francisco (US)
- East Carolina University (US)
- University of Michigan (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1212/nxi.0000000000200580
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00