A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann–Sträussler–Scheinker disease mutation
, and confirmed the antibody's ability to differentiate between infectious and uninfected prion samples. Our study demonstrates the feasibility of a model-based approach for prion vaccine design and targeting of the infectious prion protein, providing groundwork for future development of not only potential prion therapeutic interventions, but also targeting related neurodegenerative disorders characterized by protein misfolding.
Authors
- Madeleine Fleming
- Virginie Coustou (ORCID: https://orcid.org/0000-0002-6327-2113)
- Lyudmyla Dorosh (ORCID: https://orcid.org/0000-0002-5224-4045)
- Glenn C. Telling (ORCID: https://orcid.org/0000-0002-6294-1805)
- Ansgar B. Siemer
- Vineet Rathod
- Nathalie Daude (ORCID: https://orcid.org/0000-0001-5217-7826)
- Maria Stepanova
- Andrew Fang (ORCID: https://orcid.org/0000-0002-6678-6822)
- Silvia A. Cervantes
- Camilo Duque Velásquez (ORCID: https://orcid.org/0000-0001-5997-748X)
- Xiongyao Wang
- Yongliang Wang (ORCID: https://orcid.org/0000-0002-5480-9927)
- Shelaine C. Fleck
- Holger Wille
- David Westaway
- Judd Aiken
- Debbie McKenzie
- Brian Tancowny
- Xinli Tang
- Sven J. Saupe
Institutions
- University of Lethbridge (CA)
- University of Southern California (US)
- University of Alberta (CA)
- University of Calgary (CA)
- Harbin Institute of Technology (CN)
- Women and Children’s Health Research Institute (CA)
- Institut de Biochimie et Génétique Cellulaires (FR)
- Colorado State University (US)
Publication Details
- Journal
- Acta Neuropathologica
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1007/s00401-026-03015-4
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Results Driven Agriculture Research
- Alberta Conservation Association
- University of Alberta
- Canada Foundation for Innovation
- Alberta Innovates
- National Institutes of Health
- University of California, San Francisco
- Natural Sciences and Engineering Research Council of Canada
- Alberta Prion Research Institute
- Creutzfeldt-Jakob Disease Foundation