UBE2M-mediated EGFR neddylation drives keratinocyte proliferation in psoriasis
. Mechanistically, we showed that UBE2M enhances keratinocyte proliferation and migration by increasing neddylation-mediated modification of EGFR, thereby stabilizing and activating EGFR. The results highlight the therapeutic potential of targeting UBE2M and neddylation in psoriasis treatment.
Authors
- Ningning Dang (ORCID: https://orcid.org/0000-0002-5139-0876)
- Zhenzhen Yan (ORCID: https://orcid.org/0009-0006-1206-5495)
- Yibo Wang
- Yixuan Fu
- Shuhong Huang
- Qixia Wang
- Linlin Xu
- Xiang Lin (ORCID: https://orcid.org/0009-0007-6826-5733)
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1016/j.isci.2026.115784
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China