Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study—A Nonrandomized Clinical Trial on Large and Giant Aneurysms

BACKGROUND AND OBJECTIVES: The prospective single-arm nonrandomized SCENT (Surpass Intracranial Aneurysm Embolization System Pivotal) trial on flow diverter treatment of large and giant intracranial aneurysms (IA) was analyzed for patients' age and IA characteristics affecting stroke and occlusion rates over 5 years (Trial registration NCT01716117). METHODS: Impact on major ipsilateral stroke and IA occlusion was studied by stratifying age as 65 years and younger vs older than 65. Kaplan-Meier estimates of time to both endpoints, stratified by age, were created. Univariate predictors of time-to-stroke were analyzed using univariable proportional hazards regression models. Limited bivariable modeling was also attempted. RESULTS: = .417. CONCLUSION: Age older than 65 was associated with an increased risk of stroke and predictive of incomplete healing and increased time to healing.

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Journal
Neurosurgery Open
Published
2026-04-17
DOI
https://doi.org/10.1227/neuprac.0000000000000222
Primary Topic
Intracranial Aneurysms: Treatment and Complications
Type
article
Field-Weighted Citation Impact
0.00

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article

Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study—A Nonrandomized Clinical Trial on Large and Giant Aneurysms

Koji Ebersole, Ahmet Baki Dogan, Philip M. Meyers, B Welch et al.
Neurosurgery Open
Intracranial Aneurysms: Treatment and Complications
article

Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study—A Nonrandomized Clinical Trial on Large and Giant Aneurysms

Koji Ebersole, Ahmet Baki Dogan, Philip M. Meyers, B Welch, Mark D. Bain, A Coon, Ajay K. Wakhloo, J. Mocco, Paul Jenkins, Joost de Vries, Peter T. Kan, Giuseppe Lanzino, for the SHaRe and IPHCC Investigators, Philipp Taussky, Aquilla S. Turk, Ricardo A. Hanel, Ajit S. Puri, Pascal M. Jabbour, Adnan H. Siddiqui
article en

Abstract

BACKGROUND AND OBJECTIVES: The prospective single-arm nonrandomized SCENT (Surpass Intracranial Aneurysm Embolization System Pivotal) trial on flow diverter treatment of large and giant intracranial aneurysms (IA) was analyzed for patients' age and IA characteristics affecting stroke and occlusion rates over 5 years (Trial registration NCT01716117). METHODS: Impact on major ipsilateral stroke and IA occlusion was studied by stratifying age as 65 years and younger vs older than 65. Kaplan-Meier estimates of time to both endpoints, stratified by age, were created. Univariate predictors of time-to-stroke were analyzed using univariable proportional hazards regression models. Limited bivariable modeling was also attempted. RESULTS: = .417. CONCLUSION: Age older than 65 was associated with an increased risk of stroke and predictive of incomplete healing and increased time to healing.

Neurosurgery OpenVol. 7(2)
Tufts University (US), Prisma Health (US), Beth Israel Deaconess Medical Center (US), Cleveland Clinic (US), Mayo Clinic (US), Radboud University Nijmegen (NL), Oregon Health & Science University (US), University of Massachusetts Chan Medical School (US), Cornell University (US), Thomas Jefferson University Hospital (US), Beth Israel Deaconess Hospital (US), The University of Kansas Health System (US), Presbyterian Hospital (US), Carondelet Health (US), The Neurological Institute (US), Stryker (United States) (US), The University of Texas Medical Branch at Galveston (US), University at Buffalo, State University of New York (US), Columbia University (US), The University of Texas Southwestern Medical Center (US)
Abbott Laboratories, Patient-Centered Outcomes Research Institute, Medical University of South Carolina, Stryker, Canon Medical Systems USA, National Institutes of Health
Good health and well-being
Openalex Percentile: Top 11%
Intracranial Aneurysms: Treatment and Complications
DOIOpen Access PDFOpenAlex
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