Concordance and Prognostic Impact of Tumor–Stroma Ratio and Tumor-Infiltrating Lymphocytes in Preoperative Biopsies and Matched Surgical Specimens in Oral Squamous Cell Carcinoma
TSR evaluated in preoperative biopsies was highly concordant with results in main resection specimens and may provide significant information for OSCC prognostication, risk stratification, and treatment decisions. In contrast, TILs evaluated in biopsies showed poor concordance with main resection specimens and failed to demonstrate prognostic significance.
Authors
- Jaroslav Michálek (ORCID: https://orcid.org/0000-0002-3454-5880)
- Michal Hendrych (ORCID: https://orcid.org/0000-0002-1024-7408)
- Michal Herman
- Michal Mozoľa (ORCID: https://orcid.org/0000-0002-4165-9675)
- Peter Tvrdý
- Markéta Hermanová (ORCID: https://orcid.org/0000-0002-3889-0905)
- Zdeněk Bednařík (ORCID: https://orcid.org/0000-0002-5746-8814)
- Richard Pink (ORCID: https://orcid.org/0000-0001-6361-4649)
- Jana Zapletalová (ORCID: https://orcid.org/0000-0002-9694-2486)
- Katerina Brachtlova (ORCID: https://orcid.org/0009-0000-9016-7805)
Institutions
- Masaryk University (CZ)
- University Hospital Olomouc (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Diagnostics
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/diagnostics16081202
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00