Transcriptomic Evidence Reveals the IIS–FOXO–SOD2 Axis as a Core Anti-Aging Pathway in Long-Lived Queens of Odontotermes formosanus
reproductives counteract the potential lifespan-reducing effects of chronic IIS activation by maintaining or enhancing FOXO activity, thereby supporting DNA repair, antioxidant defenses, and cellular homeostasis. The IIS-FOXO-SOD2 axis is identified as a key regulator of reproductive longevity in higher termites, offering new insights into the molecular mechanisms behind lifespan extension in social insects.
Authors
- Yongjian Xie (ORCID: https://orcid.org/0000-0001-8225-7720)
- Dayu Zhang (ORCID: https://orcid.org/0000-0001-7197-2382)
- Hao Chen (ORCID: https://orcid.org/0000-0003-1571-7509)
- Yiyang Chen (ORCID: https://orcid.org/0000-0003-0152-8563)
- Dandan Qiao
Institutions
- Zhejiang A & F University (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Experimental Center of Forestry in North China (CN)
Publication Details
- Journal
- Insects
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/insects17040432
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China