Higher glymphatic system activity is linked to longer prodromal stage in isolated REM sleep behavior disorder: a possible protective factor
) was 11.07 ± 5.68 years. Higher ALPS-index was positively correlated with longer iRBD symptom duration (rho = 0.409, p = 0.002). Although the ALPS-index did not predict phenoconversion in the entire cohort, post-hoc analysis of converters revealed that patients with higher ALPS-index exhibited more than nine years longer time to conversion than patients with lower ALPS-index (χ² = 13.075, p < 0.001). These findings suggest that preserved glymphatic function may be associated with prolonged prodromal stability in iRBD.
Authors
- Karel Šonka (ORCID: https://orcid.org/0000-0001-5773-9656)
- Petr Dušek (ORCID: https://orcid.org/0000-0003-4877-9642)
- Jiří Nepožitek (ORCID: https://orcid.org/0000-0002-3339-5286)
- Jiří Keller (ORCID: https://orcid.org/0000-0002-6799-7840)
- Stanislav Mareček (ORCID: https://orcid.org/0009-0004-0773-5373)
- Tomáš Krajča (ORCID: https://orcid.org/0000-0002-4746-1539)
- Veronika Rottová
Institutions
- Charles University (CZ)
- University Hospital in Motol (CZ)
- General University Hospital in Prague (CZ)
- Czech Technical University in Prague (CZ)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1038/s41531-026-01339-2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Karlova v Praze
- Ministerstvo Zdravotnictví Ceské Republiky
- Agentura Pro Zdravotnický Výzkum České Republiky
- NextGenerationEU