Cytomorphology of Sinonasal Glomangiopericytoma: A Rare Case and Review of Literature

Sinonasal glomangiopericytoma is a mesenchymal neoplasm of pericytic derivation with characteristic CTNNB1 gene mutation usually arising from the sinonasal cavity. Given its monomorphic and cellular morphology, it can mimic mesenchymal, epithelial, or even lymphoid neoplasms. Reports highlighting the cytology of sinonasal glomangiopericytoma have not been, to our knowledge, documented yet. Herein, we shed light on the cytomorphology of a rare case of sinonasal glomangiopericytoma arising in the ethmoid sinus of a 77-year-old male, review the literature, and discuss the differential diagnosis of such a challenging entity.

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Publication Details

Journal
Diagnostic Cytopathology
Published
2026-04-16
DOI
https://doi.org/10.1002/dc.70125
Primary Topic
Soft tissue tumor case studies
Type
article
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article

Cytomorphology of Sinonasal Glomangiopericytoma: A Rare Case and Review of Literature

Norris Hollie, Hamza Gokozan, Rana Naous
Diagnostic Cytopathology
Soft tissue tumor case studies
article

Cytomorphology of Sinonasal Glomangiopericytoma: A Rare Case and Review of Literature

Norris Hollie, Hamza Gokozan, Rana Naous
article en

Abstract

Sinonasal glomangiopericytoma is a mesenchymal neoplasm of pericytic derivation with characteristic CTNNB1 gene mutation usually arising from the sinonasal cavity. Given its monomorphic and cellular morphology, it can mimic mesenchymal, epithelial, or even lymphoid neoplasms. Reports highlighting the cytology of sinonasal glomangiopericytoma have not been, to our knowledge, documented yet. Herein, we shed light on the cytomorphology of a rare case of sinonasal glomangiopericytoma arising in the ethmoid sinus of a 77-year-old male, review the literature, and discuss the differential diagnosis of such a challenging entity.

Diagnostic Cytopathology
The Ohio State University Wexner Medical Center (US)
Openalex Percentile: Top 4%
Soft tissue tumor case studies
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