The diagnostic and prognostic utility of blood metagenomic next-generation sequencing for invasive pulmonary aspergillosis
but requires integration with serological biomarkers to differentiate IPA from colonization. The RPM can offer prognostic utility. A multimodal strategy is crucial for early diagnosis and improving outcomes in high-risk patients. IMPORTANCE: , and elevated lactate dehydrogenase as independent predictors of 28-day mortality, providing clinically actionable tools for risk stratification.
Authors
- Sifen Lu (ORCID: https://orcid.org/0000-0003-4891-1682)
- Ting Niu (ORCID: https://orcid.org/0000-0003-1580-1014)
- Yongzhao Zhou
- Lang Min (ORCID: https://orcid.org/0009-0009-8507-4546)
- Xinzhu Tang (ORCID: https://orcid.org/0009-0006-8156-9558)
- Laduona Wang
- Liyan Guo
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Precision Research (United States) (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1128/spectrum.03384-25
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Sichuan Province
- National Key Research and Development Program of China