A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration
-induced vascularization trigger endochondral ossification. Finite element analysis and transcriptome studies reveal the role of wavy CCL in alleviating stress concentration and protecting articular cartilage, thus presenting high efficacy in rabbits' osteochondral repair. Collectively, this study emphasizes the indispensability of wavy CCL in multileveled scaffolds toward osteochondral regeneration.
Authors
- Xuemiao Liu (ORCID: https://orcid.org/0000-0002-8978-909X)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Xing Wang (ORCID: https://orcid.org/0000-0003-3926-1999)
- Fuzhen Yuan
- Mingze Du
- Kang Tian
Institutions
- Dalian Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Peking University Third Hospital (CN)
- Institute of Chemistry (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1038/s41467-026-71810-4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality