Association of genetic polymorphism with intra-articular and masticatory muscle temporomandibular disorders: a systematic review protocol

OBJECTIVE: This review aims to assess the association between the genetic polymorphisms and the occurrence, severity of signs and symptoms, and sex-specific presentation of temporomandibular disorder subtypes. INTRODUCTION: Temporomandibular disorders (TMDs) are multifaceted conditions that affect the temporomandibular joint, masticatory muscles, and related structures. Genetic predisposition is one of the etiological factors for TMDs. Various genetic variations have been linked to the onset of TMD and progression of symptoms. ELIGIBILITY CRITERIA: This study will include primary research investigating the association of genetic polymorphisms in TMDs by considering studies with a specific subtype of TMD or where the progression has a genetic predisposition. Eligible studies will be published in English, have a control group, and diagnose TMD using a standard tool. METHODS: Relevant articles will be searched in PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), ProQuest Dissertations and Theses, Google Scholar, Science Direct, CINAHL Complete (EBSCOhost), Open Access Theses and Dissertations (OATD) (EBSCOhost), Web of Science Core Collection, and Wiley Open Library. The articles will be screened and assessed for eligibility by 2 independent reviewers. Methodological quality will be assessed using a standardized JBI instrument. If the data are sufficient, a meta-analysis will be conducted; otherwise, the findings will be presented in narrative format, including tables and figures. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. REVIEW REGISTRATION: PROSPERO CRD42024627433.